Reaction Types of Samarium Fluoride SmF3
The difference in the reaction of Samarium Fluoride SmF3 is that the active halogenation reaction is in the same reaction system as the saddle compound. This enables halogenation and intramolecular reductive addition of aryl groups and can be used in cyclization reactions. Matsuda succeeded in obtaining an eight-membered ring skeleton of vinyl alcohol by reacting a halogenated allyl group with the Barbier of the sole.
In the presence of HMPA, use Samarium Fluoride SmF3, so satisfactorily is not required. Barbier reactions also occur between molecules. Molander successfully obtained the eight-membered ring skeleton of variecolin through two Samarium Fluoride SmF3. Since then, it has not been difficult to find that transition metal salts and light can be combined to activate SMLs. Reformatsky response Mukaiyama mediated through smlz.
Samarium Fluoride SmF3 reaction synthesized the most difficult 8-membered ring "2" in the paclitaxel skeleton. The precursors were successfully prepared through a five-step reaction. In the first step, enol silination, followed by displacement of the RYLα site, followed by saddleyl αmethylation. The presence of HMPA suppresses the nucleophilicity of the oxygen atom in the enol and selectively removes the TBS protection of the segment in HCl.