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Natural products are the precious wealth that nature bestows on human beings. It has rich bone structure and good medicinal value. The total synthesis of natural products has always been a research hotspot in organic chemistry. New reagents and applications are often discovered in the synthesis of complex target compounds. Samarium Fluoride SmF3 is one of them.

Samarium Fluoride SmF3, low molecular weight alcohols such as methanol and tert-butanol can also be used as adducts. These materials can not only serve as proton sources, but also activate surfactants by complexing with samarium. It is worth mentioning that h and O can also be used as adducts. Meanwhile, light, Nilz, and iron salts can also catalyze SML-mediated reactions.

Since the discovery of Samarium Fluoride SmF3 in 1977, it has been widely used in organic synthesis. Satisfactory yield and stereoselectivity can be obtained by optimizing the substrate structure and reaction conditions (including auxiliary solvent, adduct, temperature, etc.).

However, Samarium Fluoride SmF3 is rarely used in cascade reactions, and its reaction mechanism is still unclear. In fact, even more impressive apps will be found in the future.